Current Studies

Current Studies

I. We have the following active studies:

    1. Glyconutrient supplement on Alzheimer’s disease
    2. Gingko Biloba, grape seed and green tea extract, and other micronutrients on cognition in healthy, elderly adults
    3. Methylated vitamin B complex on depression
    4. Aerobic and strengthening exercise training on metabolic syndrome in HIV
    5. Magnesium sulfate on depression
    6. Pulsed electro-magnetic frequency on chronic knee pain

1. Glyconutrient supplement on Alzheimer’s disease
The purpose of this study is to investigate the health outcomes of a 12-month course of glyconutrients (monosaccharides) among Alzheimer’s patients. Subjects are assessed at baseline and 3-, 6-, 9-, and 12-month follow-up with a battery of measures for cognitive functioning, disease severity, activities of daily living, and quality of life. Physiological parameters are tested at baseline and 12 months: monocytes/lymphocytes (CD4, CD8, CD45, CD14, CD34, CD90, and CD95), cytokines (IL-2, IL-4, IL-6, IL-8, IL-10, IL-1alpha, IL-1beta, IFN-gamma, TNF-alpha, MCP-1, VEGF and EGF), and micro array analysis of RNA of the stem cells to identify significantly expressed genes before and after supplementing with a regimen of glyconutrients.

2. Gingko biloba, grape seed and green tea extract, and other micronutrients on cognition in healthy, elderly adults
The study is a 6-month, randomized, double-blind, placebo-controlled trial to evaluate the efficacy of a regimen of whole-food nutritional supplements on cognition in 90 persons (60+ years of age) with no history of significant cognitive deficits. Participants will be assessed at baseline and 3 and 6 months, and the study will consist of three treatment arms, including: (a) Ginkgo Synergy and Choline; (b) OPC Synergy and Catalyn; and © placebo. Additionally, the study will examine inflammation (12-panel cytokines), functional status, and quality of life.

3. Methylated vitamin B complex on depression
The study is a 60-day, randomized, double-blind, placebo-controlled trial to evaluate the efficacy of methylated vitamin B complex (Max Stress B™) for improving depressive and anxiety symptoms according to the Beck Depression and Anxiety Inventories, respectively, in 60 patients (18+ years of age) diagnosed with major depression or other forms of depressive disorders and an elevated level of homocysteine (> 10 µmol/L) at baseline. Secondary outcomes include body composition, blood pressure and pulse, level of physical activity, dietary intake, and quality of life. Participants will be assessed at baseline and 30 and 60 days. The study will consist of two treatment arms: (a) vitamin B complex and (b) placebo.

4. Aerobic and strengthening exercise training on metabolic syndrome in HIV
The purpose of the study is to evaluate the efficacy of a 12-week, combined exercise (cardiovascular and strength) training for improving immune functioning (CD4 T cells and viral load) and metabolic syndrome variables (total, LDL, and HDL cholesterol, triglycerides, blood pressure, waist and hip circumference, and body mass index) in HIV+ patients (18+ years of age) on stable HAART.

5. Magnesium sulfate on depression
This is a randomized, double-blind, two-phase, cross-over study in 20 male and female volunteers with mild to moderate depression. In Phase 1, each subject will be randomized in a double-blind fashion to receive either IV infusion of Magnesium Sulfate or 5% Dextrose followed by washout for 5 days then crossover to receive either 5% Dextrose or IV infusion of Magnesium Sulfate followed by Phase 2 in which each subject will receive in an open-label fashion oral Magnesium Citrate daily for 3 months total duration. Assessments will occur at baseline, Day 1, Day 2, Day 7, Day 8, Day 14, Day 45, Day 75 and Day 105. There will be a telephone interview/follow-up on a weekly basis except for the week of assessment following the oral dosing on Day 14.

6. Pulsed electro-magnetic frequency on chronic knee pain
The purpose of the study is to determine and compare the clinical effectiveness of pulsed electro-magnetic frequency (PEMF) devices of different power levels in providing a reduction in pain and inflammation as well as increased range of motion and a return to a normal health and activity level. PEMF devices are non-heat producing and will be tested in the treatment of individuals with chronic knee pain using a combination of survey, physical activity, biomechanical, neuromuscular, and hematological assessments of inflammation, pain, and range of motion. Forty-eight subjects will be recruited. Subjects will include males and post-menopausal females ages 45-65 years. The subject population to be selected and studied will include individuals with a medical history of diagnosed chronic knee pain.